por TCMVET | Sep 7, 2024 | Cáncer y tumores en perros
Diagnosing mesothelioma in pets involves a combination of clinical examination, fluid analysis, and imaging techniques. Since the symptoms often mimic other diseases, a thorough diagnostic approach is essential.
1. Fluid Analysis
One of the most telling diagnostic tools is the analysis of the effusion (fluid) that builds up in the body cavities. While the fluid in mesothelioma cases is often classified as a modified transudate, its analysis can provide clues about the presence of cancer cells. This fluid buildup typically signals that the body’s natural filtration processes are being compromised by the cancer.
2. Radiografía (rayos X)
X-rays are commonly used to detect the presence of fluid within the chest or abdominal cavities, but they do not usually reveal the tumor itself. In most cases, only the effusion will be visible on an X-ray, making further imaging necessary.
3. Tomografías computarizadas
Computed tomography (CT) scans offer a more detailed view than X-rays and can reveal the presence of tumors or thickening of the mesothelium. CT scans are often used to locate tumors and assess their spread within the body cavities.
4. Surgical Biopsy
In many cases, a surgical exploration or biopsy is required to confirm the diagnosis of mesothelioma. This involves taking tissue samples from the affected area, which can then be examined under a microscope to identify cancerous cells. Because mesothelioma often grows infiltratively (invading surrounding tissues), it can be difficult to surgically remove the entire tumor.
Treatment Options for Mesothelioma in Pets
Treating mesothelioma in dogs and cats can be challenging due to the infiltrative nature of the disease. Unfortunately, complete surgical removal of the tumor is often impossible, especially if the cancer has spread extensively throughout the cavities.
1. Cirugía
Surgery is usually performed for diagnostic purposes, such as obtaining a biopsy sample, rather than for curative purposes. In some cases, surgery can help reduce the tumor burden, but full excision is rare due to the tumor’s invasive nature.
2. Quimioterapia
Chemotherapy may be used to slow the progression of mesothelioma, although its effectiveness varies from case to case. In some pets, chemotherapy can help manage the fluid buildup and reduce tumor size, improving the quality of life.
3. Cuidados paliativos
Because mesothelioma is often diagnosed at an advanced stage, many treatment plans focus on palliative care. This may involve draining the effusion to relieve symptoms like difficulty breathing or abdominal discomfort. Regular monitoring and supportive care can significantly improve a pet’s comfort in the later stages of the disease.
Prognosis for Pets with Mesothelioma
The prognosis for pets with mesothelioma is generally poor, as the disease is often diagnosed late due to its subtle symptoms and infiltrative nature. However, with appropriate management, some pets can live comfortably for several months following diagnosis. Early detection and a tailored treatment plan can help extend the pet’s life and maintain their quality of life for as long as possible.
Mesothelioma is a serious and rare form of cancer that affects both dogs and cats, most commonly in their later years. Understanding the symptoms, diagnostic methods, and treatment options for this disease is crucial for providing the best care for pets. While mesothelioma often has a poor prognosis, early detection and a combination of palliative care, surgery, and chemotherapy can help manage the condition and improve a pet’s quality of life.
If your pet is showing signs of respiratory distress, abdominal swelling, or unexplained weight loss, it’s important to consult a veterinarian as soon as possible for a thorough evaluation.
por TCMVET | Sep 5, 2024 | Cáncer y tumores en perros
Secondhand smoke, long known for its harmful effects on humans, has also been linked to serious health problems in pets, particularly dogs. One of the most concerning health risks for dogs exposed to secondhand smoke is the increased likelihood of developing lung tumors. Although lung cancer is relatively rare in dogs, research suggests that dogs exposed to cigarette smoke may be at a significantly higher risk of developing this type of cancer. In this article, we will explore the dangers of secondhand smoke for dogs, the signs of lung tumors, and steps you can take to protect your pet.
How Secondhand Smoke Affects Dogs
Secondhand smoke consists of the toxic chemicals released from burning cigarettes, cigars, or other tobacco products, as well as the smoke exhaled by the smoker. Dogs that live in households where smoking occurs are exposed to these harmful substances, which can accumulate in their bodies over time.
Just like in humans, exposure to secondhand smoke in dogs can lead to respiratory issues, irritation, and chronic lung conditions. However, the most serious consequence of prolonged exposure is the increased risk of developing lung tumors, particularly in older dogs. These tumors can develop in the lungs, bronchial tubes, or even the nasal passages, depending on the dog’s size and breed.
Why Are Dogs Vulnerable to Secondhand Smoke?
- Sensitive Respiratory Systems
Dogs have sensitive respiratory systems, and their lungs are not equipped to handle prolonged exposure to harmful chemicals like those found in tobacco smoke. Breeds with shorter noses, such as Bulldogs, Pugs, and Boxers, are particularly vulnerable to inhaling toxins because they have less filtration capacity in their nasal passages.
- Proximity to Smoke
Dogs often spend time close to their owners, making them more likely to inhale secondhand smoke. Since dogs tend to lie on the floor, they are also exposed to thirdhand smoke, which consists of toxic residues that settle on surfaces such as carpets, furniture, and pet beds. Over time, these chemicals can build up in a dog’s lungs and increase the risk of cancer.
- Weaker Immune Systems in Older Dogs
Senior dogs, especially those over the age of 10, have weaker immune systems, which makes them more susceptible to the harmful effects of secondhand smoke. As a dog’s immune system declines with age, their ability to repair damaged cells diminishes, increasing the likelihood of cancerous growths.
The Link Between Secondhand Smoke and Lung Tumors in Dogs
Studies have shown that dogs living in smoking households are at a higher risk of developing lung cancer compared to those living in smoke-free environments. This increased risk is due to the carcinogenic substances found in tobacco smoke, such as nicotine, formaldehyde, and benzene, which can damage lung tissue over time. Inhalation of these toxic substances can cause cellular changes in the lungs, leading to the development of malignant tumors.
Certain dog breeds may be at an even higher risk due to their genetic predisposition to cancer or respiratory sensitivity. For example, long-nosed breeds like Collies and Greyhounds tend to develop nasal cancers more frequently, while shorter-nosed breeds are more likely to develop lung cancers.
Signs of Lung Tumors in Dogs
Detecting lung tumors in dogs can be difficult, as symptoms may not appear until the cancer has progressed. However, some common signs that may indicate lung cancer include:
- Persistent coughing: A chronic cough that does not resolve with treatment may be a sign of lung cancer.
- Respiración dificultosa: Labored or rapid breathing can indicate a problem with the lungs.
- Lethargy and fatigue: A noticeable decrease in energy levels may be a sign of illness.
- Pérdida de peso: Unexplained weight loss could indicate a serious health problem.
- Pérdida de apetito: A lack of interest in food is another potential indicator of lung cancer.
If your dog exhibits any of these symptoms and has been exposed to secondhand smoke, it is crucial to seek veterinary attention. Early detection of lung tumors can significantly improve treatment outcomes.
Diagnosis and Treatment of Lung Cancer in Dogs
When lung cancer is suspected, a veterinarian will perform diagnostic tests such as x-rays or ultrasounds to check for abnormal growths in the lungs. A biopsy may also be performed to determine if the growth is malignant. Once a diagnosis is confirmed, treatment options can include:
- Cirugía: If the tumor is localized, surgical removal may be possible. This is often the best treatment option for early-stage lung cancer.
- Quimioterapia y radioterapia: In cases where surgery is not an option or the cancer has spread, chemotherapy and radiation may be used to shrink tumors and slow the progression of the disease.
- Cuidados paliativos: For advanced lung cancer, palliative care may be recommended to manage symptoms and improve the dog’s quality of life.
How to Protect Your Dog from Secondhand Smoke
The best way to protect your dog from the dangers of secondhand smoke is to create a smoke-free environment. Here are a few steps you can take:
- Do not smoke indoors: If you smoke, do so outside and away from your pets to minimize their exposure to harmful chemicals.
- Avoid smoking in enclosed spaces: Never smoke in the car or other confined spaces where your dog may be exposed to concentrated smoke.
- Clean your home regularly: Vacuum carpets and wash your dog’s bedding frequently to remove thirdhand smoke residues from surfaces.
- Quit smoking: The most effective way to protect both your dog and yourself from the harmful effects of smoking is to quit altogether.
Secondhand smoke is a serious health hazard for dogs, increasing their risk of developing lung tumors and other respiratory problems. Pet owners who smoke should be aware of the dangers and take steps to minimize their dog’s exposure to tobacco smoke. By creating a smoke-free environment, you can help protect your dog’s health and reduce the likelihood of lung cancer and other diseases.
por TCMVET | Sep 5, 2024 | Cáncer y tumores en perros
As dogs age, they become more susceptible to various health issues, including cancer. One type of cancer that disproportionately affects senior dogs is lung cancer. While lung cancer in dogs is relatively rare, older dogs are at a higher risk of developing this disease. Understanding the reasons behind this increased risk and the symptoms of lung cancer in senior dogs can help pet owners take preventive steps and ensure early detection.
Why Are Senior Dogs at Greater Risk for Lung Cancer?
- Natural Aging Process
As dogs age, their bodies undergo a natural decline in cellular regeneration and immune function. This means that older dogs are more likely to experience mutations in their cells, which can lead to the development of cancer. Cells in the lungs, like other tissues in the body, are subject to this process, making senior dogs more vulnerable to lung tumors.
- Longer Exposure to Environmental Toxins
Senior dogs have been exposed to environmental toxins for a longer period of time compared to younger dogs. Toxins such as pollutants, chemicals, and even secondhand smoke can accumulate in their bodies over the years. These substances can damage lung tissue, making it more likely for tumors to form. Dogs living in urban environments or households where smoking occurs may face an even higher risk.
- Sistema inmunológico debilitado
The immune system plays a crucial role in identifying and destroying cancerous cells before they can spread. However, as dogs age, their immune system weakens, making it less effective at eliminating abnormal cells. This decline in immune function increases the likelihood of lung cancer developing in senior dogs.
- Chronic Respiratory Conditions
Older dogs are more prone to chronic respiratory conditions such as bronchitis or infections, which can weaken lung tissue over time. Chronic inflammation in the lungs can create an environment where cancer cells are more likely to thrive. Dogs with a history of respiratory issues should be monitored closely for signs of lung cancer as they age.
Common Symptoms of Lung Cancer in Senior Dogs
Lung cancer in dogs often develops without noticeable symptoms in its early stages, making it challenging to detect. However, as the disease progresses, certain signs may appear. These include:
- Persistent cough: A dry, persistent cough that does not resolve over time may be an early sign of lung cancer.
- Respiración dificultosa: Labored breathing or shortness of breath could indicate a problem with the lungs.
- Letargo: A noticeable decrease in energy levels or reluctance to exercise can be a warning sign.
- Pérdida de apetito: If your senior dog suddenly loses interest in food, it could be a sign of illness.
- Pérdida de peso inexplicable: Rapid or unexplained weight loss is often a symptom of cancer in dogs.
- Nasal discharge: Any unusual discharge from the nose may be related to lung problems.
If your senior dog exhibits any of these symptoms, it’s essential to consult a veterinarian for a thorough examination. Early detection of lung cancer can improve the chances of successful treatment.
Diagnosis of Lung Cancer in Senior Dogs
If lung cancer is suspected in a senior dog, a veterinarian will typically begin with imaging tests such as x-rays or ultrasounds to check for tumors in the lungs. These tests can reveal the size, location, and spread of any abnormal growths. In some cases, additional tests like CT scans or biopsies may be needed to confirm a diagnosis and determine the type of lung cancer.
Types of Lung Cancer in Senior Dogs
There are several types of lung cancer that can affect dogs, the most common being adenocarcinoma, which originates in the cells lining the lung tissues. Other types include carcinoma de células escamosas y bronchial carcinoma. These cancers can vary in terms of aggressiveness and potential to spread (metastasize) to other organs.
In older dogs, tumors are often more aggressive due to the weakened immune system and prolonged exposure to risk factors.
Treatment Options for Lung Cancer in Senior Dogs
Treatment for lung cancer in senior dogs depends on the type and stage of the cancer. Common treatment options include:
- Cirugía: If the tumor is localized and has not spread, surgery to remove the affected lung lobe may be an option. This can be a highly effective treatment if the cancer is caught early.
- Quimioterapia: Chemotherapy may be used in cases where surgery is not possible or when the cancer has spread to other parts of the body. Chemotherapy helps slow the progression of the disease, though it may not cure it.
- Radioterapia: Radiation is sometimes used in conjunction with surgery or chemotherapy to shrink tumors and alleviate symptoms.
- Cuidados paliativos: In cases where the cancer is advanced, palliative care may be recommended to improve the dog’s quality of life and manage symptoms like pain or difficulty breathing.
How to Prevent Lung Cancer in Senior Dogs
While lung cancer cannot always be prevented, there are steps you can take to reduce your dog’s risk:
- Avoid secondhand smoke: Do not smoke around your dog, as exposure to secondhand smoke increases the risk of lung cancer.
- Keep your dog active: Regular exercise helps maintain lung health and boosts the immune system.
- Provide a healthy diet: A balanced diet rich in antioxidants can help support your dog’s overall health.
- Regular veterinary checkups: Annual or biannual vet visits are crucial, especially for senior dogs, to catch any signs of cancer early.
As dogs age, they become more susceptible to lung cancer due to factors such as a weakened immune system, longer exposure to toxins, and chronic respiratory conditions. Pet owners should be aware of the symptoms of lung cancer in senior dogs and seek veterinary care if any signs arise. Early diagnosis and appropriate treatment can improve your dog’s quality of life and longevity.
por TCMVET | Sep 5, 2024 | Cáncer y tumores en perros
Primary lung tumors in dogs are extremely rare, affecting only 4 out of 100,000 dogs. Despite their rarity, recent years have seen an increase in the diagnosis of lung tumors in canines. This rise may be attributed to the longer lifespans of dogs, which naturally exposes them to more age-related diseases. Additionally, increased exposure to secondhand smoke has been identified as a possible contributing factor. While primary lung cancer can be difficult to detect, understanding the causes and risk factors can help dog owners remain vigilant and take the necessary precautions.
What Are Primary Lung Tumors in Dogs?
Primary lung tumors in dogs are growths that originate in the lung tissue itself, as opposed to secondary tumors, which spread to the lungs from other parts of the body. Though these types of tumors are rare, they are most commonly found in senior dogs, with the average age of diagnosis being 10 years. Unlike other forms of cancer, primary lung tumors do not appear to show any breed or gender predisposition, meaning all dogs are potentially at risk.
Types of Primary Lung Tumors
The most common type of primary lung tumor in dogs is adenocarcinoma, which accounts for 80% of all primary lung cancers in canines. Adenocarcinomas develop in the lining of the lung tissue, primarily affecting the bronchi, bronchioles, or alveoli. These tumors can range from slow-growing to highly aggressive.
The second most common type is carcinoma de células escamosas, which arises in the cells lining the airways. While not as prevalent as adenocarcinomas, squamous cell carcinomas are still significant in terms of risk.
Other, less common types of primary lung tumors in dogs include:
- Chondromas
- Sarcomas
- Fibromas
- Plasmacytomas
Each of these tumor types presents unique challenges in terms of diagnosis and treatment.
Causas y factores de riesgo
- Aging
One of the primary risk factors for lung cancer in dogs is age. Primary lung tumors are most often seen in dogs over 10 years of age. As dogs live longer due to advances in veterinary care and nutrition, the likelihood of age-related diseases like cancer naturally increases.
- Secondhand Smoke
Just like in humans, secondhand smoke has been linked to an increased risk of lung cancer in dogs. Dogs living in households where smoking occurs may inhale carcinogens, which could damage their lung tissue over time, leading to the development of tumors.
- Toxinas ambientales
Exposure to environmental pollutants such as chemicals, asbestos, and other airborne toxins may also increase the risk of lung tumors in dogs. Urban environments, where air pollution is more common, might pose a higher risk for developing such cancers.
- Pre-existing Health Conditions
Certain pre-existing health conditions, like chronic bronchitis or lung infections, can weaken the lungs and potentially increase the risk of developing cancerous tumors. Dogs with a history of respiratory illnesses should be monitored closely as they age.
- Genetics
While there is no specific breed predisposition for primary lung tumors, genetic mutations or hereditary factors may still play a role in some cases. However, more research is needed in this area to establish any definitive genetic links.
Diagnosis of Primary Lung Tumors
Diagnosing primary lung tumors in dogs can be challenging. Symptoms often do not appear until the tumor has grown significantly, making early detection difficult. Common signs to watch for include:
- Persistent coughing
- Respiración dificultosa
- Letargo
- Pérdida de apetito
- Pérdida de peso inexplicable
A veterinarian may perform chest x-rays or an ultrasound to detect any abnormal growths in the lungs. However, these images can sometimes be misleading, as non-cancerous conditions like lung abscesses, cysts, or granulomas (caused by fungal infections or parasites) may mimic the appearance of a tumor. Definitive diagnosis typically requires a biopsy to determine if the mass is malignant.
Opciones de tratamiento
Once diagnosed, the treatment plan for primary lung cancer will depend on the type, size, and stage of the tumor. Extirpación quirúrgica of the tumor is the most common and effective treatment, particularly if the tumor is confined to one lung lobe and has not metastasized. Dogs have a good chance of recovery post-surgery, as the lung can regenerate.
In cases where surgery is not possible, chemotherapy o radiation therapy may be considered, especially for more aggressive or inoperable tumors. However, these treatments are usually aimed at prolonging life rather than providing a cure.
While primary lung tumors in dogs are rare, the incidence appears to be rising due to increased lifespans and environmental factors like secondhand smoke exposure. Dog owners should remain vigilant, particularly as their pets age, and seek prompt veterinary care if any respiratory issues arise. Early diagnosis and treatment can significantly improve a dog’s quality of life and longevity.
por TCMVET | Sep 5, 2024 | Cáncer y tumores en perros
Liver cancer in dogs, while not among the most common forms of cancer, can pose a serious threat to your pet’s health if not caught early. According to research, liver tumors account for approximately 1.5% of all canine tumors. Though this percentage is relatively small, early detection plays a crucial role in successful treatment. Understanding the symptoms and types of liver cancer can help pet owners ensure timely veterinary care for their dogs.
What is Liver Cancer in Dogs?
In many cases, liver tumors in dogs are metastatic, meaning that they have spread from other parts of the body rather than originating in the liver itself. These metastatic tumors are often benign, which offers a more favorable prognosis.
However, in some instances, dogs can develop primary liver tumors, which start directly in the liver. The most common type of primary liver cancer in dogs is Carcinoma hepatocelular, accounting for over 50% of primary liver cancers. Although these tumors tend to remain confined to the liver, they are often malignant and can be challenging to treat.
Causes and Risk Factors for Canine Liver Cancer
The exact causes of liver cancer in dogs remain unclear. Unlike some other cancers, liver cancer doesn’t seem to have a specific breed predisposition. However, age is a significant factor, with liver cancer being more common in dogs over 10 years old. Some studies also suggest that male dogs may be at slightly higher risk, but this has not been conclusively proven.
Symptoms of Liver Cancer in Dogs
Detecting liver cancer early can drastically improve treatment outcomes. Pet owners should watch for the following symptoms and seek veterinary attention if they notice any of these signs:
- Pérdida de apetito
- Pérdida de peso inexplicable (especially a rapid loss of over 10% body weight)
- Lethargy or fatigue
- Increased thirst
- Vomiting or diarrhea
- Noticeable abdominal mass
- Jaundice (yellowing of the skin or eyes)
- Frequent urination or blood in urine
- Confusion or disorientation
These symptoms may indicate liver cancer, but they can also be related to other health issues. It is important to visit a veterinarian for a proper diagnosis.
Diagnosing Liver Cancer in Dogs
If a veterinarian suspects liver cancer, they will typically begin with a physical examination to detect any masses or abnormalities in the abdominal area. Blood and urine tests may be conducted to evaluate liver function. However, the most definitive way to diagnose liver cancer is through imaging tests like x-rays o ultrasounds, which can identify tumors or growths in the liver.
Types of Liver Cancer in Dogs
Liver cancers in dogs are categorized based on their appearance and how they spread:
- Massive Tumors: These are large, singular masses that typically form in one area of the liver. They are less likely to spread than other types.
- Nodular Tumors: These smaller masses appear in multiple locations within the liver and are more likely to metastasize to other organs.
- Diffuse Cancer: This form consists of cancer cells dispersed throughout the liver, making it difficult to treat as there are no distinct tumors to remove.
A Hepatocellular Adenoma refers to a benign liver tumor, which, though not as dangerous, may still require surgical removal based on its size and location.
Treatment Options for Liver Cancer in Dogs
The treatment plan for liver cancer in dogs varies depending on the type, size, and spread of the tumor. Common treatments include:
- Extirpación quirúrgica: The most effective treatment for many liver cancers involves surgically removing the tumor. Since the liver can regenerate, dogs often recover well after surgery, though they may need ongoing dietary and health management.
- Quimioterapia y radiación: These therapies may be recommended in combination with surgery or as a standalone treatment, depending on the cancer’s stage and type.
- Medicación: Some cancers may be managed with medications that help slow their progression or alleviate symptoms.
Every case of liver cancer is unique, and a veterinary oncologist can provide personalized treatment recommendations based on your dog’s specific situation.
Liver cancer in dogs is a serious condition that requires early detection and prompt treatment for the best possible outcomes. Being aware of the symptoms, such as sudden weight loss, jaundice, or a noticeable abdominal mass, can help dog owners take swift action. Regular vet checkups and monitoring your dog’s health are essential, particularly for older dogs, to catch any signs of liver cancer early.
por TCMVET | Sep 5, 2024 | Cáncer y tumores en perros
Cancer is one of the leading health concerns for dogs, affecting numerous breeds regardless of their size, age, or pedigree. Some dog breeds, however, are genetically more prone to developing certain types of cancer than others. Understanding which dog breeds are at a higher risk can help owners be more vigilant and proactive about their pets’ health. In this article, we will explore the dog breeds that are more susceptible to cancer and what signs pet owners should watch for.
Breeds Most Prone to Cancer
- perros perdigueros de oro Golden Retrievers are one of the most well-known breeds prone to cancer. Studies suggest that approximately 60% of Golden Retrievers will develop some form of cancer in their lifetime, with hemangiosarcoma and lymphoma being the most common. These cancers can be aggressive, so early detection is crucial.
- boxeadores Boxers are another breed highly susceptible to cancer, particularly mast cell tumors, which affect the skin. They are also prone to lymphoma and brain tumors. Regular check-ups with a veterinarian can help catch these issues before they become life-threatening.
- Bernese Mountain Dogs Bernese Mountain Dogs are at high risk of developing histiocytic sarcoma, a particularly aggressive type of cancer that affects the spleen, liver, and other organs. Unfortunately, the prognosis for this cancer is often poor, which is why routine health monitoring is essential.
- rottweilers Rottweilers are commonly affected by osteosarcoma, a type of bone cancer. This aggressive cancer can spread quickly, often requiring amputation of the affected limb. Early signs, such as lameness or swelling in the limbs, should be addressed immediately.
- Pastores alemanes German Shepherds are known to develop hemangiosarcoma, particularly in the spleen or heart. This type of cancer is often diagnosed in its later stages because it shows few early symptoms, making regular veterinary screenings especially important for this breed.
- perros perdigueros de labrador Labrador Retrievers, although generally healthy, are also prone to cancer, particularly lymphoma and mast cell tumors. These cancers can affect various organs and require immediate treatment for the best prognosis.
- beagles Beagles are more likely to develop bladder cancer than other breeds. Bladder cancer, while treatable, can spread quickly if not caught early. Beagle owners should be on the lookout for signs like blood in urine or difficulty urinating.
- caniches Standard Poodles are prone to several types of cancer, including lymphoma and hemangiosarcoma. Regular vet check-ups and a healthy lifestyle can help reduce the risks and detect cancer early.
Signs to Watch For
Cancer symptoms in dogs can vary depending on the type and location of the tumor, but common signs include:
- Pérdida de peso inexplicable
- Bultos o protuberancias en el cuerpo.
- Respiración dificultosa
- Lameness or swelling in the limbs
- Pérdida de apetito
- Unusual bleeding or discharge
If any of these symptoms appear, it is crucial to consult with a veterinarian as soon as possible.
Early Detection and Prevention
Although there is no guaranteed way to prevent cancer, early detection can significantly improve a dog’s chances of survival. Regular veterinary check-ups, a balanced diet, and maintaining a healthy weight can reduce the risk of cancer in dogs. Genetic testing can also be helpful for owners of high-risk breeds, as it may indicate a predisposition to specific types of cancer.
While many dog breeds are susceptible to cancer, early detection and preventative care can make a substantial difference in treatment outcomes. Pet owners should stay informed about their breed’s health risks and maintain regular communication with their veterinarian to ensure their dog leads a long, healthy life.
ES 
EN 
NL 
IT 
PL 
DA 
PT 
ID 
SV 
FR 
EL 
DE 
JA 
KO 
ZH 